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Dr. Thomas Allison, a Consultant in Cardiovascular Diseases and Internal Medicine, and the Director of Stress testing at Mayo Clinic in Rochester, MN, reviews his article appearing in the December 2014 issue of Mayo Clinic Proceedings, which validates the established equation for men, reveals a different heart-rate response in women, and elucidates conditions that may affect peak heart rate performance abilities in both, which will allow clinicians to more accurately establish baselines for diagnostic testing. Available at: http://tinyurl.com/otwlbra